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SAB4300701 Sigma-Aldrich

Anti-Id2 antibody produced in rabbit

affinity isolated antibody

Synonym: Anti-GIG8, Anti-ID2A, Anti-ID2H

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Properties

Related Categories Alphabetical Index, Antibodies, I-IG, Primary Antibodies
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 1:500-1:1000
species reactivity   rat, human, mouse
mol wt   ~15 kDa
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
isotype   IgG
antibody product type   primary antibodies
concentration   1 mg/mL
immunogen sequence   (S-P-V-R-S)
NCBI accession no.   NM_002166.4
UniProt accession no.   Q02363
Gene Information   human ... Id2(3398)

Description

General description

Id2 (inhibitor of DNA binding 2) belongs to the HLH (helix–loop–helix) family. It is located on human chromosome 2p25.

The antibody detects endogenous level of total Id2 protein.

Immunogen

Peptide sequence around aa. 5-9 (S-P-V-R-S), according to the protein NP_002157.2

Target description

ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Id2 (inhibitor of DNA binding 2) knockdown decreases the upregulation of N-cadherin, vimentin and Snail and promotes the expression of E-cadherin. It has the ability to interact with Rb protein and block its antiproliferative activity. It can prevent the separation of cells, stimulate multiplication of cell and help in reprogramming of Hodgkin lymphoma cells, the oncogenic AP-1 transcription factor FRA2 (fos-related antigen 2) and the oncogenic tyrosine kinase CSF-1 receptor.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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