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SAB4300962 Sigma-Aldrich

Anti-GIP antibody produced in rabbit

affinity isolated antibody

Synonym: GIP, Gastric inhibitory polypeptide, Glucose-dependent insulinotropic polypeptide

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, GD-GL, Primary Antibodies
clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry: 1:10- 1:50
  western blot: 1:200-1:1000 (Cell Lysate)
species reactivity   human
mol wt   17 kDa
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
isotype   IgG
Quality Level   100
antibody product type   primary antibodies
concentration   0.5 mg/mL
accession no.   NP_004114.1
UniProt accession no.   P09681
Gene Information   human ... GIP(2695)

Description

General description

Glucose-dependent insulinotropic polypeptide (GIP) or gastric inhibitory polypeptide is a 42-amino acid gastrointestinal regulatory peptide, expressed in K cells of the small intestine and in cells of the submandibular salivary gland. The gene encoding GIP is localized on human chromosome 17.

Specificity

The antibody detects endogenous levels of total GIP protein.

Immunogen

Fusion protein corresponding to a region derived from internal residues of human gastric inhibitory polypeptide

Physical form

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

In the presence of glucose, glucose-dependent insulinotropic polypeptide (GIP) induces insulin secretion. It acts as an antagonist of the human GIP receptor. Aberrations in GIP are associated with visceral fat accumulation. The protein has been studied to have a protective function in obesity and atherosclerosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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