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SAB4500666 Sigma-Aldrich

Anti-P62 DOK antibody produced in rabbit

affinity isolated antibody

Synonym: DOK1, Docking protein 1, Downstream of tyrosine kinase 1, p62(dok), pp62

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Properties

Related Categories Alphabetical Index, Antibodies, P-PA, Primary Antibodies
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   ELISA: 1:4000
  immunohistochemistry: 1:50-1:100
  western blot: 1:500-1:1000
species reactivity   human, rat, mouse
mol wt   antigen 52 kDa
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
concentration   ~1 mg/mL
NCBI accession no.   Q99704
UniProt accession no.   Q99704
Gene Information   human ... DOK1(1796)

Description

General description

Anti-P62 DOK Antibody detects endogenous levels of total P62 DOK protein.

Docking protein-1 (DOK1) is an adaptor protein. It is located on human chromosome 2p13.

Immunogen

The antiserum was produced against synthesized peptide derived from human p62 Dok.

Immunogen Range: 329-378

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

In tissues, docking protein-1 (DOK1) blocks the pathways of growth factor and immune response. In mast cells, DOK1 participates in the protein tyrosine kinase (PTK) pathway. It controls platelet-derived growth factor (PDGF)-BB-triggered glioma cell movement.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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