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  • SAB4502019 - Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit

SAB4502019 Sigma-Aldrich

Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit

affinity isolated antibody

Synonym: NOTC1, Notch homolog 1, neurogenic locus notch 1, notch 1 (translocation-associated), translocation-associated (Drosophila) (TAN1)

  •  NACRES NA.41



Related Categories Alphabetical Index, Antibodies, NK-NR, Primary Antibodies
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   ELISA: 1:5000
  immunohistochemistry: 1:50-1:100
  western blot: 1:500-1:1000
species reactivity   rat, human, mouse
mol wt   antigen 110 kDa
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
concentration   ~1 mg/mL
Featured Industry   Research Pathology
NCBI accession no.   P46531
UniProt accession no.   P46531
Gene Information   human ... NOTCH1(4851)


General description

The NOTCH1 gene is mapped to human chromosome 9q34 and encodes a member of the NOTCH family of proteins. The gene encodes a large transmembrane protein that contains an extracellular domain with 36 tandem epidermal growth factor (EGF)-like repeats and three cysteine-rich Notch/LIN-12 repeats, a six ankyrin repeat-containing intracellular domain, and a transactivation domain.

Anti-NOTCH1 (Cleaved-Val1754) Antibody detects endogenous levels of fragment of activated NOTCH1 (Cleaved-Val1754) protein.


The antiserum was produced against synthesized peptide derived from human Notch 1.

Immunogen Range: 1735-1784


Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit has been used in immunohistochemistry (IHC).

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

The Notch1 protein is a transmembrane receptor that induces pluripotent progenitor cells to form T-cells and facilitates the assembly of pre–T cell receptor complexes in immature thymocytes. It participates in an intracellular signaling pathway that regulates cellular differentiation, cell fate and lateral inhibition. Mutations in this gene have been associated with human blood cancers, abnormal cardiovascular calcification, aortic valve disease, and human T cell acute lymphoblastic leukemia.

Features and Benefits

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles


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