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  • SAB4502369 - Anti-HDAC8 antibody produced in rabbit

SAB4502369 Sigma-Aldrich

Anti-HDAC8 antibody produced in rabbit

affinity isolated antibody

Synonym: FKSG78, G-protein coupled receptor 95, GPR87, GPR95, Probable G-protein coupled receptor 87



Related Categories Alphabetical Index, Antibodies, H1-HE, Primary Antibodies
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   ELISA: 1:20000
  immunohistochemistry: 1:50-1:100
  western blot: 1:500-1:1000
species reactivity   rat, human, mouse
mol wt   antigen 41 kDa
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
concentration   ~1 mg/mL
NCBI accession no.   Q9BY41
UniProt accession no.   Q9BY41
Gene Information   human ... HDAC8(55869)


General description

Anti-HDAC8 Antibody detects endogenous levels of total HDAC8 protein.

The HDAC8 (histone deacetylase 8) gene is mapped to human chromosome Xq13.1. The encoded protein belongs to the class 1 histone deacetylase family.


The antiserum was produced against synthesized peptide derived from human HDAC8.

Immunogen Range: 5-54

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

The HDAC8 (histone deacetylase 8) protein is significantly involved in cartilage development and matrix-specific gene transcription by catalyzing histone acetylation. HDAC8 has Zn2+-dependent hydrolase activity that deacetylates the acetyl lysine residues of both histone and non-histone proteins. Deacetylation of structural maintenance of chromosome protein 3(SMC3) by HDAC8 is necessary for recycling of cohesin complex during cell cycle. Mutation in the gene is observed in Cornelia de Lange syndrome which is characterised by mental retardation and facial deformity.

Features and Benefits

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles


Antibody Basics

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Western Blot Protocol | Immunoblotting Protocol

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