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  • SAB4502895 - Anti-MUNC-18A antibody produced in rabbit

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SAB4502895 Sigma-Aldrich

Anti-MUNC-18A antibody produced in rabbit

affinity isolated antibody

Synonym: N- Sec1, STB1, STXB1, STXBP1, Syntaxin binding protein 1

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, MUE-MZ, Primary Antibodies
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   ELISA: 1:40000
  immunofluorescence: 1:100-1:500
  immunohistochemistry: 1:50-1:100
species reactivity   human, rat, mouse
mol wt   antigen 67 kDa
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
concentration   ~1 mg/mL
NCBI accession no.   P61764
UniProt accession no.   P61764
Gene Information   human ... STXBP1(6812)

Description

General description

Anti-MUNC-18A Antibody detects endogenous levels of total MUNC-18A protein.

The gene STXBP1 (syntaxin binding protein 1) is mapped to human chromosome 9q34.1. The encoded protein is 594 amino acids long, which is expressed in all tissues with highest levels in retina and cerebellum.

Immunogen

The antiserum was produced against synthesized peptide derived from human MUNC-18a.

Immunogen Range: 279-328

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Biochem/physiol Actions

The gene STXBP1 (syntaxin binding protein 1) encodes a regulatory protein of the components of the SNARE (soluble NSF/ N-ethylmaleimide-sensitive factor attachment protein receptor) complex that are crucial for neurotransmission. It is a neuronal protein that functions in synaptic vesicle release. Mutations in this gene have been associated with early infantile epileptic encephalopathy. It causes autosomal dominant mental retardation and nonsyndromic epilepsy.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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