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  • SAB4700005 - Monoclonal Anti-CD95 antibody produced in mouse

SAB4700005 Sigma-Aldrich

Monoclonal Anti-CD95 antibody produced in mouse

clone LT95, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-FAS

  •  NACRES NA.41



Related Categories Alphabetical Index, Antibodies, Antibodies for Flow Cytometry, Antibodies to CD and Related Antigens, F-FA,
conjugate   unconjugated
clone   LT95, monoclonal
biological source   mouse
application(s)   flow cytometry: suitable
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
antibody form   purified immunoglobulin
isotype   IgG1
Quality Level   100
antibody product type   primary antibodies
concentration   1 mg/mL
NCBI accession no.   NM_000043.3
UniProt accession no.   P25445
Gene Information   human ... FAS(355)


General description

CD95, also known as Fas (fatty acid synthase) cell surface death receptor/APO-1, is encoded by the gene mapped to human chromosome 10q23.31. The encoded protein belongs to the tumor necrosis factor receptor superfamily and is expressed on a variety of cells including activated T and B cells. CD95 contains a death domain.

The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.


HUT-78 human T cell lymphoma cell line


Monoclonal Anti-CD95 antibody produced in mouse has been used as a apoptosis inducer.

Physical form

Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.

Biochem/physiol Actions

CD95/ Fas (fatty acid synthase) cell surface death receptor interacts with its natural ligand (FasL/CD95 L) and plays a vital role in regulation of T-cell homeostasis, by promoting apoptosis via activation-induced cell death (AICD). Mutation in the gene has been associated with the development of Sézary syndrome (SS) and Canale–Smith syndrome. CD95 gene loss can be used as a genetic marker of PSA recurrence after radical prostatectomy.

Features and Benefits

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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