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SAB5500167 Sigma-Aldrich

Anti-PSMA antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP29, tissue culture supernatant

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Properties

Related Categories Alphabetical Index, Antibodies, PS-PS, Primary Antibodies, Rabbit Monoclonal Antibodies,
conjugate   unconjugated
clone   SP29, monoclonal
biological source   rabbit
application(s)   immunohistochemistry: 1:100
species reactivity   human (tested)
species reactivity (predicted by homology)   pig, mouse, rat, bovine, dog
shipped in   wet ice
storage temp.   2-8°C
antibody form   tissue culture supernatant
isotype   IgG
antibody product type   primary antibodies
recombinant   expressed in proprietary host
UniProt accession no.   Q04609
Gene Information   human ... FOLH1(2346)

Description

General description

PMSA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region.

Immunogen

Synthetic peptide derived from C-terminus of human PSMA.

Physical form

0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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