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  • SAB5600057 - Anti-p38 MAPK Phospho (pT180/pY182) antibody, Rabbit monoclonal

SAB5600057 Sigma-Aldrich

Anti-p38 MAPK Phospho (pT180/pY182) antibody, Rabbit monoclonal

recombinant, expressed in HEK 293 cells, clone RM243, purified immunoglobulin



Related Categories Alphabetical Index, Antibodies, P-PA, Primary Antibodies, Recombinant Rabbit Monoclonal Antibodies More...
clone   RM243, monoclonal
  recombinant monoclonal
application(s)   immunoblotting: 1:1000-1:2000
  immunohistochemistry: 1:500-1:1000
species reactivity   human
form   buffered aqueous glycerol solution
shipped in   wet ice
storage temp.   −20°C
antibody form   purified immunoglobulin
isotype   IgG
antibody product type   primary antibodies
recombinant   expressed in HEK 293 cells
NCBI accession no.   1432


General description

The mitogen activated protein kinase (MAPK) gene codes for a serine/threonine protein kinase which is found to be expressed in majority of cells. The MAPK gene is mapped to human chromosome 6p21.31 and the encoded protein consists of 90 to 360 amino acids residues. MAPKs are divided into three subtypes : extracellular signal-regulated kinases (ERK), c-Jun amino-terminal kinases (JNK) and p38 MAPK (p38).


This antibody reacts to p38 MAPK only when dual phosphorylation at Thr180 and Tyr182 is observed. There is no cross-reactivity with p38 MAPK without dual phosphorylation at Thr180 and Tyr182.


Synthetic phospho-peptide corresponding to human Phospho-p38 MAPK (Thr180/Tyr182)


Anti-p38 MAPK Phospho (pT180/pY182) antibody, Rabbit monoclonal has been used for immunodetection.

Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Mitogen activated protein kinase (MAPK) participates in transdifferentiation of adipocytes in myoblast by regulating adipogenic and adipolysis metabolism. p38 MAPK is associated with various biological processes as such as cell proliferation and differentiation, cell adhesion, migration. It mediates pro-apoptotic signal during apoptosis, contributing either to cell death or survival.. p38 MAPK is known to mediate a number of metabolic pathways by controlling transcription, mRNA stability, chromatin remodelling and protein synthesis. During initial process of tumorigenesis, It acts as a tumor suppressor, while it might promote metastasis in the later stages of the same. p38 MAPK gets activated in response to growth factors, oxidative stress, proinflammatory cytokines and DNA damage.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Safety & Documentation

Safety Information

NONH for all modes of transport
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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