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SAB5700096 Sigma-Aldrich

Anti-CYP3A4 antibody produced in rabbit

Synonym: CP33, CP34, CYP3A3, CYP3A4, CYP3A, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1

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Properties

clone   polyclonal
biological source   rabbit
application(s)   immunofluorescence: 1:20-1:100
  immunohistochemistry: 1:20-1:50
  western blot: 1:500-1:1000
species reactivity   human, rat, mouse
mol wt   57
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
concentration   0.77 mg/ml
UniProt accession no.   P08684
Gene Information   human ... CYP3A4(1576)

Description

General description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A4 (NP_059488.2).

Physical form

PBS with 0.02% sodium azide,pH7.3.

Storage and Stability

Store at 4℃. Avoid freeze / thaw cycles.

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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