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SAB5700239 Sigma-Aldrich

Anti-XIAP antibody produced in rabbit

Synonym: API3, BIRC4, IAP-3, ILP1, MIHA, XIAP, XLP2, hIAP-3, hIAP3

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Properties

clone   polyclonal
biological source   rabbit
application(s)   immunofluorescence: 1:50-1:100
  immunohistochemistry: 1:50-1:100
  western blot: 1:500-1:2000
species reactivity   human, rat, mouse
mol wt   56
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
concentration   1.39 mg/ml
UniProt accession no.   P98170
Gene Information   human ... XIAP(331)

Description

General description

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human XIAP (NP_001158.2).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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