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SAB5700452 Sigma-Aldrich

Anti-Phospho-ACLY-S455 antibody produced in rabbit

Synonym: ACL, ACLY, ATPCL, CLATP

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Properties

clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry: 1:50-1:100
  immunoprecipitation (IP): 1:50-1:100
  western blot: 1:500-1:2000
species reactivity   human, mouse, rat
mol wt   119
  120
  91
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
concentration   1.15 mg/ml
UniProt accession no.   P53396
Gene Information   human ... ACLY(47)

Description

General description

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Immunogen

A synthetic phosphorylated peptide around S455 of human ACLY (NP_001087.2).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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