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SAB5700614 Sigma-Aldrich

Anti-IGF1R antibody produced in rabbit

Synonym: CD221, IGF1R, IGFIR, IGFR, JTK13

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Properties

clone   polyclonal
biological source   rabbit
application(s)   immunofluorescence: 1:50-1:200
  immunohistochemistry: 1:50-1:200
  western blot: 1:500-1:2000
species reactivity   human, mouse, rat
mol wt   154
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
concentration   2.5 mg/ml
UniProt accession no.   P08069
Gene Information   human ... IGF1R(3480)

Description

General description

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 660-760 of human IGF1R (NP_000866.1).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Safety & Documentation

Safety Information

WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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