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SBR00001 Sigma-Aldrich

Vancomycin hydrochloride

Ready Made Solution, 100 mg/mL in DMSO, 0.2 μm filtered

  • CAS Number 1404-93-9

  • Empirical Formula (Hill Notation) C66H75Cl2N9O24 · xHCl

  • Molecular Weight 1449.25 (free base basis)

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Properties

biological source   Streptomyces orientalis
sterility   0.2 μm filtered
form   liquid
concentration   100 mg/mL in DMSO
color   colorless to faint tan
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   −20°C

Description

General description

Vancomycin is a glycopeptide antibiotic, which was initially isolated from Streptomyces orientalis. It is effective against multidrug-resistant MRSA strain (methicillin-resistant Staphylococcus aureus). However, it is nephrotoxic as it is mainly excreted by the kidneys. It has a core heptapeptide having aliphatic amino acids at positions 1 and 3. It is mainly effective against gram-positive bacteria.

Application

Vancomycin hydrochloride may be used-
• for the assessment of the antimicrobial activity of vancomycin hydrochloride against Mycobacterium tuberculosis in nonreplicating persistence (NRP) using low-oxygen-recovery assay (LORA) and against a luciferase reporter strain of M. tuberculosis in a fermentor-grown culture adapted to low oxygen conditions
• for the estimation of biomass in a culture of various strains of bacteria
• as a positive control for E. coli and Staphylococcus aureus in antibacterial activity assay.

Biochem/physiol Actions

Vancomycin is bactericidal in nature, where it inhibits the synthesis of peptidoglycan. It forms hydrogen bond with the peptidoglycan precursor UDP-N-acetylmuramylpentapeptide, and forms a stoichiometric 1:1 complex. Thus, it prevents the growth of the glycan polymer of peptidoglycan by transglycosylase enzyme. It is a frequently used antibiotic for the treatment of peritonitis caused by gram-positive bacteria in patients with continuous ambulatory peritoneal dialysis. In patients with cirrhosis, it is used to control portal systemic encephalopathy. Mice with Clostridium difficile infection (CDI) had better clinical outcome when treated with vancomycin as opposed to the outcome on treatment with metronidazole.

Packaging

10ML

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
WGK Germany 
2
Flash Point(F) 
188.6 °F
Flash Point(C) 
87 °C

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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