EMAIL THIS PAGE TO A FRIEND
SMB00579 Sigma-Aldrich

Tacalcitol

≥99% (HPLC)

Synonym: (1α,3β,5Z,7E,24R)-9,10-secocholesta-5,7,10(19)-triene-1,3,24-triol, 1α,24R-dihydroxycholecalciferol, 1α,24R-dihydroxyvitamin D3

  • CAS Number 57333-96-7

  • Empirical Formula (Hill Notation) C27H44O3

  • Molecular Weight 416.64

  •  MDL number MFCD00866623

  •  PubChem Substance ID 329825068

  •  NACRES NA.79

Purchase

Properties

Related Categories Biochemicals and Reagents, Cell Biology, Lipids, Nutrition Research, Other Sterol Lipids,
Quality Level   200
biological source   synthetic (organic)
assay   ≥99% (HPLC)
form   powder
application(s)   HPLC: suitable
color   white to off-white
storage temp.   −20°C
SMILES string   C[C@]([C@@]1([H])[C@H](C)CC[C@@H](O)C(C)C)(CCC/2)[C@](CC1)([H])C2=C\C=C(C[C@@H](O)C[C@@H]3O)/C3=C
InChI   1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1
InChI key   BJYLYJCXYAMOFT-RSFVBTMBSA-N

Description

General description

Tacalcitol is a synthetic vitamin D3 analog. It is a vitamin D3 derivative, also known as 1α,24-dihydroxyvitamin D3.

Packaging

1 mg in glass bottle

Biochem/physiol Actions

Tacalcitol is widely used in the treatment of dermatosis due to its ability to inhibit keratinocyte proliferation and induce cell differentiation. It also has anti-inflammatory activity and has been shown to reduce cutaneous inflammation via suppression of leukocyte infiltration in skin. Tacalcitol is topically used for the treatment of psoriasis and has also been found to be effective in the treatment of acquired perforating collagenosis (APC), a rare perforating dermatosis. Studies suggest that this compound has potential for the treatment of the hereditary disorder Hailey-Hailey Disease.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?