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SMB00702 Sigma-Aldrich

Apigenin

≥97% (TLC), from citrus

Synonym: 4′,5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone

  • CAS Number 520-36-5

  • Empirical Formula (Hill Notation) C15H10O5

  • Molecular Weight 270.24

  •  Beilstein Registry Number 262620

  •  EC Number 208-292-3

  •  MDL number MFCD00006831

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Properties

InChI Key   KZNIFHPLKGYRTM-UHFFFAOYSA-N
assay   ≥97% (TLC)
form   powder
mp   >300 °C (lit.)
solubility   DMSO: 27 mg/mL
  1 M KOH: 50 mg/mL
storage temp.   −20°C
Gene Information   human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931)
mouse ... Hexa(15211)
rat ... Adora1(29290), Adora2a(25369), IL4(287287), Tnf(24835)

Description

Packaging

25, 100 mg in poly bottle

5 mg in glass bottle

Biochem/physiol Actions

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

Apigenin (ApI) is also called as 5,7,4′-trihydroxyflavone. It is a natural compound, found in several fruits and herbs, like, oranges, onions and parsley. Apigenin (ApI) blocks the development of thyroid cancer cells by attenuating epidermal growth factor receptor (EGF-R) tyrosine phosphorylation and phosphorylation of ERK mitogen-activated protein (MAP) kinase. Apigenin participates in the modulation of different signaling cascades. It possesses several functions such as, antiapoptosis, anti-inflammation, anticancer, antibacterial and antioxidant effects.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
RTECS 
LK9276000
Protocols & Articles
Peer-Reviewed Papers
15

References

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