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SMB00708 Sigma-Aldrich

Lysobactin

≥97% (HPLC)

Synonym: Katanosin B, L-Serine, D-leucyl-L-leucyl-(βR)-β-hydroxy-L-phenylalanyl-(3R)-3-hydroxy-L-leucyl-L-leucyl-D-arginyl-L-isoleucyl-L-allothreonylglycyl-(3S)-3-hydroxy-L-asparaginyl-, (11→3)-lactone

  • CAS Number 118374-47-3 (free base)

  • Empirical Formula (Hill Notation) C58H97N15O17 · xC2H4O2

  • Molecular Weight 1276.48 (free base basis)

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Biochemicals and Reagents
assay   ≥97% (HPLC)
form   powder
composition   counterion (acetate salt)
solubility   DMSO: 1 mg/mL
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   −20°C

Description

Biochem/physiol Actions

Lysobactin is a cyclic peptide with strong antibacterial activity against many bacterial strains including Staphylococcus aureus, Salmonella typhosa, and Klebsiella aerogenes. Lysobactin is reported to have MIC values of 0.2, 25, and 25 μg/mL for the above listed bacteria respectively, which is significantly higher than the potency reported for vancomycin for the same bacteria (MIC values 0.8, >100, and >100 μg/mL respectively).

The mechanism of action of lysobactin is attributed to its interaction with lipid I and lipid II in the bacterial cell wall. Lysobactin forms a 1:1 complex with lipid I and lipid II causing interference in peptidoglycan synthesis which is essential for bacterial viability. Furthermore, lysobactin was not found to be hemolytic at concentrations above its MIC.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles
Peer-Reviewed Papers
15

References

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