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SMB00802 Sigma-Aldrich

Bavachin

from Psoralea coryfolia, ≥97% (HPLC)

Synonym: (2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one, 4′,7-Dihydroxy 6-(3-methyl 2-butenyl)flavanone, Corylifolin

  • CAS Number 19879-32-4

  • Empirical Formula (Hill Notation) C20H20O4

  • Molecular Weight 324.37

  •  MDL number MFCD11617359

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Properties

Related Categories Bioflavonoids, Cancer Research, Cell Biology, Chemopreventive Agents, Nutrition Research,
assay   ≥97% (HPLC)
form   powder
storage temp.   −20°C

Description

Biochem/physiol Actions

Bavachin is a flavonoid isolated from seeds of Psoralea corylifolia. It is a phytoestrogen that activates ERα and ERβ (EC50s = 320 and 680 nM, respectively), stimulates osteoblast proliferation and differentiation, and prevents bone loss following ovariectomy in rats.

Bavachin is an inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT). The IC50 value of bavachin was reported to be 86.0 μM in ACAT assay system using rat liver microsome.

Bavachin is also reported to increase insulin-induced glucose uptake by differentiated adipocytes and myoblasts.

Physical properties

Bavachin is soluble in DMSO at 30 mg/mL. Bavachin is not water soluble.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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