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SML0006 Sigma-Aldrich

CK-666

≥98% (HPLC), powder

Synonym: 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide, CK 666, CK-0944666

  • CAS Number 442633-00-3

  • Empirical Formula (Hill Notation) C18H17FN2O

  • Molecular Weight 296.34

  •  MDL number MFCD03036271

  •  PubChem Substance ID 329825083

  •  NACRES NA.77

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Properties

Related Categories Actin Inhibitors and Probes, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: ≥25 mg/mL
storage temp.   2-8°C
SMILES string   Cc1[nH]c2ccccc2c1CCNC(=O)c3ccccc3F
InChI   1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
InChI key   UXRKUKRXVWJFER-UHFFFAOYSA-N

Description

Application

CK-666 may be used to study Arp2/3-mediated structural changes in cells.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents its movement into active conformation.

CK-666 is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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