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SML0010 Sigma-Aldrich

LY-334370 hydrochloride hydrate

≥98% (HPLC), powder

Synonym: 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate

  • Empirical Formula (Hill Notation) C21H22FN3O · HCl · xH2O

  • Molecular Weight 387.88 (anhydrous basis)

  •  MDL number MFCD11519957

  •  PubChem Substance ID 329825086

  •  NACRES NA.77

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Properties

Related Categories Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   H2O: ≥5 mg/mL (warmed)
originator   Eli Lilly
storage temp.   2-8°C
SMILES string   Cl.CN1CCC(CC1)c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23
InChI   1S/C21H22FN3O.ClH/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15;/h2-7,12-14,23H,8-11H2,1H3,(H,24,26);1H
InChI key   DGPDGAPZTPSHBL-UHFFFAOYSA-N

Description

Application

LY-334370 hydrochloride hydrate may be used to study 5-HT 1F-mediated cell signaling.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

LY-334370 hydrochloride is a selective 5-HT1F receptor agonist.

LY-334370 modulates the transmission in the mouse trigeminal system and inhibits the neuronal responses within rat Sp5C by inhibiting c-Fos activation. It shows efficacy in aborting migraine attacks.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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