SML0016 Sigma-Aldrich


Synonym: α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile

  • Empirical Formula (Hill Notation) C26H18N4O2S

  • Molecular Weight 450.51



Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   yellow
solubility   DMSO: ≥5 mg/mL (;warmed DMSO)
storage temp.   room temp



CCG-63802 may be used to study G-protein-mediated cell signaling.


5, 25 mg in glass bottle

Biochem/physiol Actions

GCC-63802 binds to RGS4 and blocks interaction with Goa (IC50 = 1.9 uM). RGS4 (Regulator of G protein Signaling) is one of the RGP proteins responsible for terminating mu opioid receptor signaling. RSG proteins are GTPase activators, and drive G protein subunits to an inactive, GDP-bound form.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at

This compound is featured on the G Proteins (Heterotrimeric) and Opioid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

Please Enter a Lot Number

Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles


Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

G Proteins (Heterotrimeric)

Heterotrimeric G proteins, comprising α, β and γ subunits, respond to extracellular signals generated by activated seven-transmembrane (7TM) receptors by modulating intracellular effector proteins su...
Keywords: Adhesion, Atomic absorption spectroscopy, Gene expression, Ligands, Phosphorylations, Rearrangements, Respiratory

Opioid Receptors

Opioid receptors are distributed widely in brain and found in spinal cord and peripheral sensory and autonomic nerves. There are three well-characterized members of the opioid receptor family, design...
Keywords: Analgesics, Atomic absorption spectroscopy, Gastrointestinal, Gene expression, Ligands, Respiratory, Transduction

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?