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SML0033 Sigma-Aldrich

Itopride hydrochloride

≥98% (HPLC)

Synonym: N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy benzamidehydrochloride, N-[p-[2-(dimethylamino)ethoxy]benzyl]veratramide hydrochloride

  • CAS Number 122892-31-3

  • Empirical Formula (Hill Notation) C20H26N2O4 ·HCl

  • Molecular Weight 394.89

  •  MDL number MFCD00881710

  •  PubChem Substance ID 329825103

  •  NACRES NA.77

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Description

General description

Itopride hydrochloride is a new prokinetic drug.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Itopride hydrochloride enhances the gastrointestinal motility by blocking the activity of dopamine on the D2 receptors, on the post-synaptic cholinergic nerves and by inducing the liberation of acetylcholine in the myenteric plexus. It also inhibits the hydrolysis of the released acetylcholine with the help of acetylcholinesterase.

Itopride is an acetylcholinesterase (AChE) inhibitor and D2 dopamine receptor antagonist. Itopride is used as a gastroprokinetic agent.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antihypertensive Agents

Agents that inhibit angiontensin-converting enzymes (ACE) and angiotensin II formation are essential to cardiovascular medicine.1 These inhibitors are used not only to treat essential hypertension an...
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, PAGE, Reductions

Peer-Reviewed Papers
15

References

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