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SML0038 Sigma-Aldrich

Fluvastatin sodium hydrate

≥98% (HPLC)

Synonym: (±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   KKEMYLLTGGQWCE-PMRANXHDSA-M
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to tan
solubility   H2O: ≥9 mg/mL
originator   Novartis
storage temp.   2-8°C

Description

Application

Fluvastatin sodium hydrate has been used:
• to examine its effect on β -glucan-induced training on immunity
• to investigate the effect of statins on the number of uncoupling protein 1 (UCP1)+ cells
• to determine its effect on insulin degrading enzyme (IDE) secretion from astrocytes
• to treat and study its effect on human umbilical vein endothelial cells (HUVECs) in vitro

Fluvastatin sodium hydrate has been used:
• to test its anti-hepatitis C virus (HCV) activity
• as a cholesterol inhibitor
• to study its effects on β-glucan-induced monocyte immune training

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Fluvastatin has antifungal activity.

Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Antilipemic Agents

Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
Sami Barghshoon
BioFiles v7 n5, 2012, 21–24
Keywords: Anti-inflammatory agents, Cardiovascular, Chemical vapor deposition, Clinical, Diabetes, Inflammation, Oxidations, Pharmaceutical, Transcription

Discover Bioactive Small Molecules for Lipid Signaling Research

Within mammalian cells, a multitude of lipid compounds are found with a variety of cellular functions, including structural components of cell membranes and as second messengers in cell signaling pat...
Keywords: Absorption, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell signaling, Diabetes, Digestions, Diseases, Growth factors, Hormones, Inflammation, Lipid Metabolism, Lipid signaling, Metabolism

Peer-Reviewed Papers
15

References

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