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SML0046 Sigma-Aldrich

NSC 668036 hydrate

≥98% (HPLC)

Synonym: N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-Alanine-(1S)-1-carboxy-2-methylpropyl ester hydrate, N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanyl-(2S)-2-hydroxy-3-methylbutanoic acid hydrate

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation,
InChI Key   CARNRIDSPYICIM-WFGXUCIJSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to tan
solubility   H2O: ≥5 mg/mL
shipped in   wet ice
storage temp.   −20°C

Description

Other Notes

hygroscopic

Packaging

5, 25 mg in glass bottle

Application

NSC 668036 hydrate may be used in Wnt-mediated cell signaling studies.

Biochem/physiol Actions

NSC 668036 binds to the PDZ domain of the Wnt-pathway signaling molecule Disheveled (Dvl), blocking the binding and activation of Dvl by Frizzled. In Xenopus embryos, NSC 668036 inhibited Wnt3A-induced expression of the target gene Siamois and formation of secondary axes.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
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