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SML0048 Sigma-Aldrich

Salvianolic acid B

≥94% (HPLC)

Synonym: (2S,3S)-4-[(1E)-3-[(1R)-1-Carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxo-1-propen-1-yl]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylic acid 3-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl] ester, Dan Shen Suan B, Danfensuan B, Lithospermic acid B

  • CAS Number 121521-90-2

  • Empirical Formula (Hill Notation) C36H30O16

  • Molecular Weight 718.61

  •  MDL number MFCD23115783

  •  PubChem Substance ID 329825118

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, S
InChI Key   SNKFFCBZYFGCQN-VWUOOIFGSA-N
assay   ≥94% (HPLC)
form   powder
optical activity   [α]/D +95 to +115°, c = 1 in methanol
color   white to tan
solubility   H2O: ≥5 mg/mL
shipped in   wet ice
storage temp.   −20°C

Description

Application

Salvianolic acid B (Sal B) has been used to determine the inhibitory effect of Sal B on aggregation kinetics of α-synuclein by thioflavin T (ThT) fluorescence assay. It has also been used as a reference compound to confirm the reproducibility of myelophil by finger printing analysis.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Salvianolic acid B is a cell protective antioxidant and free radical scavenger being investigated for a variety of conditions from ischemic heart disorders to Alzheimer′s disease. Several mechanisms of action have been proposed including EGFR, PDGF and MMP-9 inhibition and inhibition of the TGF-β1/Smads and NF-κB signaling pathways. Salvianolic acid B acts as scavengers of reactive oxygen species, reduces the adherence of leukocytes to endothelial cells, inhibits matrix metalloproteinases and inflammation. It has cardioprotective effects as it reduces lipid peroxidation in damaged cardiac tissue and decreases the leakage of lactic acid dehydrogenase.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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