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SML0055 Sigma-Aldrich

Securinine

≥98% (HPLC)

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, S
InChI Key   SWZMSZQQJRKFBP-WZRBSPASSA-N
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D -980 to -1015 (C=1, MeOH)
color   yellow
solubility   DMSO: ≥25 mg/mL
storage temp.   2-8°C

Description

Application

Securinine was used as a standard in the synthesis of the members of Securinega alkaloid family.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Securinine is an alkaloid widely in traditional folk medicine. Long known as a GABAA antagonist, securinine was recently found to up-regulate p53 protein and to modulate the related family member p73 protein in a p53-dependent fashion, inducing p73 in the HCT116 p53(-) cells and down-regulating it in the p53(+) cells. Induction of proapoptotic protein p73 only in p53 cells could be used to target cancer cells preferentially. Securinine has been found to induce p53-independent, p73-dependent apoptosis in RKO colon cancer cells.

Features and Benefits

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
VS4115000

Documents

Certificate of Analysis

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Protocols & Articles

Articles

GABAA Receptors

GABAA receptors are responsible for the majority of neuronal inhibition in the mammalian CNS. Agonist activation results in the opening of their integral anion channel, generally leading to hyperpola...
Keywords: Anticonvulsants, Central Nervous System, Cloning, Gene expression, Ligands, Neurotransmitters, Phosphorylations, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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