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SML0057 Sigma-Aldrich

Camostat mesylate

≥98% (HPLC)

Synonym: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate; FOY 305; FOY-S 980; Foipan mesylate

  • CAS Number 59721-29-8

  • Empirical Formula (Hill Notation) C20H22N4O5·CH3SO3H

  • Molecular Weight 494.52

  •  MDL number MFCD00941410

  •  PubChem Substance ID 329825123

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Description

Packaging

10, 50 mg in glass bottle

Application

Camostat mesylate has been used to determine the effect of transmembrane protease, serine (TMPRSS) family proteases on cell-cell fusion.

Camostat mesylate may be used in cell signaling studies.

Biochem/physiol Actions

Camostat is a synthetic, orally bioavailble serine protease inhibitor.

Camostat mesylate (CM) is used to treat pancreatitis and reflux esophagitis after gastrectomy.

Camostat mesylate inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes. It also inhibits the activity of pancreatic stellate cells. Camostat mesylate regulates the cytokine expression and inflammation and is effective in the treatment of dibutyltin dichloride-induced rat pancreatic fibrosis.

Features and Benefits

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis


Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Epithelial Sodium Channels (ENaCs)

The recently discovered ENaC/degenerin gene family encodes sodium channels involved in various cell functions in metazoans. The subfamilies include the degenerins, which are part of a mechanosensory ...
Keywords: Anti-inflammatory agents, Atomic absorption spectroscopy, Gene expression, Respiratory

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

Peer-Reviewed Papers
15

References

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