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SML0075 Sigma-Aldrich

OBAA

≥98% (HPLC)

Synonym: 3-(4-octadecyl)benzoylacrylic acid, 4-(4-octadecylphenyl)-4-oxo-2-Butenoic acid

  • CAS Number 134531-42-3

  • Empirical Formula (Hill Notation) C28H44O3

  • Molecular Weight 428.65

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, O
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to tan
solubility   DMSO: ≥5 mg/mL at 60 °C
storage temp.   2-8°C

Description

Application

OBAA may be used in PLA2-mediated cell signaling studies.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

OBAA is a phospholipase A2 inhibitor and prevents the melittin-induced influx of Ca+2 in trypanosomes. It inhibits the generation of ROS when epithelial and endothelial cells are treated with cholic acid.

OBAA is a potent inhibitor of phospholipases.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Phospholipase A2 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Phospholipase A2

Phospholipase A2 (PLA2) designates a class of enzymes that hydrolyze the sn-2 ester of glycerophospholipids to produce a fatty acid and a lysophospholipid. It has become clear that some of these enzy...
Keywords: Anti-inflammatory agents, Atomic absorption spectroscopy, Catalysis, Cellular processes, Digestions, Gene expression, Indirect Immunofluorescense, Inflammation, Obesity

Peer-Reviewed Papers
15

References

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