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SML0099 Sigma-Aldrich

Fluocinonide

≥98% (HPLC)

Synonym: (6α,11β,16α)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione, Lonide

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Properties

Related Categories Angiogenic Factors, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   WJOHZNCJWYWUJD-IUGZLZTKSA-N
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D +75 to +90°, c = 1 in dichloromethane
color   white to tan
solubility   DMSO: ≥19 mg/mL
storage temp.   2-8°C

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.

Fluocinonide has been used to study its effect on T-cell proliferation.

Fluocinonide is shown to be effective in the treatment of atopic dermatitis and oral lichen planus (OLP).

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
TU3831000

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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