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SML0101 Sigma-Aldrich

Montelukast sodium hydrate

≥98% (HPLC)

Synonym: 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid sodium salt hydrate

  • Empirical Formula (Hill Notation) C35H35ClNO3S·Na · xH2O

  • Molecular Weight 608.17 (anhydrous basis)

  •  MDL number MFCD20527317

  •  PubChem Substance ID 329825159

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
InChI Key   QAXHQHBRRJHZHL-ZPQUALOVSA-M
assay   ≥98% (HPLC)
form   powder
optical activity   [α]/D +90 to +106° in methanol (c=1)
storage condition   desiccated
color   white to tan
solubility   DMSO: ≥8 mg/mL at 60 °C
originator   Merck & Co., Inc., Kenilworth, NJ
storage temp.   2-8°C

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Montelukast sodium hydrate is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is a subtype specific CysLT1 receptor antagonist.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

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Peer-Reviewed Papers
15

References

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