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SML0107 Sigma-Aldrich

Pemirolast potassium

≥98% (HPLC)

Synonym: 9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one potassium salt; BMY 26517

  • CAS Number 100299-08-9

  • Empirical Formula (Hill Notation) C10H7N6O·K

  • Molecular Weight 266.30

  •  PubChem Substance ID 329825162

  •  NACRES NA.77

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Properties

Related Categories Antagonists- Histaminergics, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Bristol-Myers Squibb,
assay   ≥98% (HPLC)
form   powder
color   light yellow to green-yellow
solubility   H2O: ≥18 mg/mL
originator   Bristol-Myers Squibb
storage temp.   2-8°C
SMILES string   [K+].CC1=CC=CN2C(=O)C(=CN=C12)c3nnn[n-]3
InChI   1S/C10H7N6O.K/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8;/h2-5H,1H3;/q-1;+1
InChI key   NMMVKSMGBDRONO-UHFFFAOYSA-N

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Pemirolast potassium is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. It Inhibits chemical mediator release from tissue mast cells and has recently also been shown to inhibit the release of peptides including substance P, neurokinin (NK) A, and calcitonin gene-related peptide (CGRP) from sensory nerves. It has been used for the treatment of allergic conjunctivitis prophylaxis of for pulmonary hypersensitivity reactions to drugs such as paclitaxel

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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