SML0110 Sigma-Aldrich

Ilicicolin F

≥98% (HPLC), from Verticillium hemipterigenum

Synonym: 8′-Acetoxyascochlorin, Acetoxy-ascochlorin, Antibiotic LL-Z 1272 ζ, Benzaldehyde, 3-[(2E,4E)-5-[(1S,2S,3S,6R)-3-(acetyloxy)-1,2,6-trimethyl-5-oxocyclohexyl]-3-methyl-2,4-pentadien-1-yl]-5-chloro-2,4-dihydroxy-6-methyl

  • CAS Number 22738-98-3

  • Empirical Formula (Hill Notation) C25H31ClO6

  • Molecular Weight 462.96



Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation,
biological source   Verticillium hemipterigenum
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: ≥10 mg/mL
  H2O: insoluble
  chloroform: soluble
  methanol: soluble
storage temp.   −20°C



Ilicicolin F may be used in cell signaling and reactions mediated by acetycholinesterase and β-glucuronidase.

Biochem/physiol Actions

Ilicicolin F belongs to the ascochlorin family of molecules. Ascochlorin is an isoprenoid antibiotic produced by Verticillium hemipterigenum. Ascochlorin and its derivatives have an inhibitory effect on mitochondrial respiration by blocking the oxidation-reduction of cytochrome b through center N of the cytochrome bc1 complex. Ilicicolins have antiviral activity. They inhibit the growth of the tobacco mosaic virus, herpes simplex virus type-1(HSV-1) and newcastle disease virus.

Compounds of the ascochlorin family such as Ilicicolin F, C, D and H show a wide range of inhibitory effects on farnesyl protein transferase (FPTase) activity, and a significant inhibitory effect on the activity of testosterone-5α-reductase. Ilicicolin C and F have a moderate inhibitory activity toward the enzymes acetylcholinesterase (AChE) and β-glucuronidase and are active against Pseudomonas syringae with IC50 values of 28.5 μg/mL.

All isolated ascochlorin analogs exhibit significant antitumor and cytotoxic activities. Ascochlorin and its homologues are usable in treating and/or preventing diseases that can be relieved by the retinoid X receptor ligand-dependent signal transcriptional regulation (i.e. hypertension, cerebrovascular diseases, rheumatoid arthritis, autoimmune diseases, complication of diabetes, arteriosclerosis etc.). Moreover, they can inhibit denaturation and/or necrosis of pancreatic Langerhans islet β-cells and therefore can sustain insulin productivity.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


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