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SML0119 Sigma-Aldrich

Acrivastine

≥98% (HPLC)

Synonym: (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic acid

  • CAS Number 87848-99-5

  • Empirical Formula (Hill Notation) C22H24N2O2

  • Molecular Weight 348.44

  •  MDL number MFCD00869830

  •  PubChem Substance ID 329825170

  •  NACRES NA.77

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Properties

Related Categories A-AM, Antagonists- Histaminergics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   DMSO: >2 mg/mL (warmed)
storage temp.   2-8°C
SMILES string   Cc1ccc(cc1)\C(=C/CN2CCCC2)c3cccc(\C=C\C(O)=O)n3
InChI   1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+
InChI key   PWACSDKDOHSSQD-IUTFFREVSA-N
Gene Information   human ... HRH1(3269)

Description

Application

Acrivastine has been used as an antihistamine to investigate the relation between the increased residence time of antihistamine at the histamine H1 receptor (H1R) and the duration of effective target-inhibition by this antagonist.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Acrivastine is a second-generation antihistamine, an H1-receptor antagonist.

Acrivastine is a second-generation antihistamine. It is a derivative of first-generation compound triprolidine. Acrivastine is effectively used for treating allergic diseases including cholinergic urticaria and histamine-medicated dermatoses.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
UD3474000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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