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SML0121 Sigma-Aldrich

BTZO-1

≥98% (HPLC)

Synonym: 2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one

  • CAS Number 99420-15-2

  • Empirical Formula (Hill Notation) C13H8N2OS

  • Molecular Weight 240.28

  •  MDL number MFCD19690951

  •  PubChem Substance ID 329825172

  •  NACRES NA.77

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Properties

Related Categories Apoptosis Inhibitors, Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecule Alphabetical Index,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: ≥7 mg/mL
originator   Takeda
storage temp.   2-8°C
SMILES string   O=C1N=C(Sc2ccccc12)c3ccccn3
InChI   1S/C13H8N2OS/c16-12-9-5-1-2-7-11(9)17-13(15-12)10-6-3-4-8-14-10/h1-8H
InChI key   GBAKVEWPYUIGHN-UHFFFAOYSA-N

Description

Application

BTZO-1 may be used in ARE-mediated gene expression studies.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BTZO-1 is a suppressor of cardiomyocyte apoptosis presumably by activation of antioxidant response element (ARE)-mediated gene expression. BTZO-1 binds to the macrophage migration inhibitory factor (MIF) that is required to activate the glutathione S-transferase Ya subunit (GST Ya) gene ARE.

Features and Benefits

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

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