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SML0126 Sigma-Aldrich

OBA-09 hydrate

≥98% (HPLC)

Synonym: 2-(1,2-Dioxopropoxy)benzoic acid hydrate, O-Pyruvoylsalicylic acid hydrate

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Properties

Related Categories Antioxidants and Cytoprotectants, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to tan
solubility   DMSO: ≥24 mg/mL
storage temp.   2-8°C
SMILES string   O.CC(=O)C(=O)Oc1ccccc1C(O)=O
InChI   1S/C10H8O5.H2O/c1-6(11)10(14)15-8-5-3-2-4-7(8)9(12)13;/h2-5H,1H3,(H,12,13);1H2
InChI key   DLKFQAHWYMEWIK-UHFFFAOYSA-N

Description

Application

OBA-09 hydrate may be used in cell signaling studies.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

OBA-09 is a neuroprotective agent. It is an ester of pyruvate and salicylic acid that acts as a multi-functional agent to protect against ischemic damages to the brain. Administration of 5 mpk OBA-09 following middle cerebral artery occlusion (MCAO) or oxygen-glucose deprivation (OGD) models of ischemic injury in rats prevents lipid peroxidation, ROS production and causes the recovery of NAD and ATP concentrations to near basal levels. The compound leads to reduction of infarct volume and also accelerates the recovery of behavioral and neurological deficits.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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