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SML0146 Sigma-Aldrich

ZL006

≥98% (HPLC)

Synonym: 4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid

  • CAS Number 1181226-02-7

  • Empirical Formula (Hill Notation) C14H11Cl2NO4

  • Molecular Weight 328.15

  •  MDL number MFCD20527326

  •  PubChem Substance ID 329825194

  •  NACRES NA.25

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Nitric Oxide Metabolism,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: ≥5 mg/mL (warmed to 60° C)
storage temp.   2-8°C
SMILES string   OC(=O)c1ccc(NCc2cc(Cl)cc(Cl)c2O)cc1O
InChI   1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21)
InChI key   RTEYSQSXRFVKTJ-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

ZL006 inhibits the ischemia-induced interaction of nNOS with postsynaptic density protein-95 (PSD-95), preventing glutamate-induced excitotoxicity and cerebral ischemic damage. It does not inhibit nNOS itself. ZL006 is brain penetrant, and has been tested in both rat and mouse models of stroke.

ZL006, a novel neuroprotectant, is also called as 5-(3, 5-dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid. It has the ability to block the interaction of neuronal nitric oxide synthase (nNOS)/postsynaptic density protein-95 (PSD-95) in co-immunoprecipitation assays of extracts from glutamate or cultured neurons and cortical brain, stimulated by ischemia.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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