EMAIL THIS PAGE TO A FRIEND
SML0151 Sigma-Aldrich

CCT036477

≥98% (HPLC)

Synonym: α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine

  • CAS Number 305372-78-5

  • Empirical Formula (Hill Notation) C21H18ClN3

  • Molecular Weight 347.84

  •  MDL number MFCD01831143

  •  PubChem Substance ID 329825199

  •  NACRES NA.77

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
  ≥98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: ≥20 mg/mL (warm to 60°C)
storage temp.   −20°C
SMILES string   Cc1[nH]c2ccccc2c1C(Nc3ccccn3)c4ccc(Cl)cc4
InChI   1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)
InChI key   IFOHRIXRQPOHQZ-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?