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SML0177 Sigma-Aldrich

AUDA

≥98% (HPLC)

Synonym: 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid

  • CAS Number 479413-70-2

  • Empirical Formula (Hill Notation) C23H40N2O3

  • Molecular Weight 392.58

  •  MDL number MFCD12912267

  •  PubChem Substance ID 329825206

  •  NACRES NA.77

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Properties

Related Categories AN-AZ, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: ≥10 mg/mL at warmed to 60 °C
storage temp.   −20°C
SMILES string   OC(=O)CCCCCCCCCCCNC(=O)NC12C[C@@H]3C[C@@H](C[C@@H](C3)C1)C2
InChI   1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28)/t18-,19+,20-,23-
InChI key   XLGSEOAVLVTJDH-UKBVAGSOSA-N

Description

Application

AUDA has been used in the inhibition of epoxide hydrolase in human macrophages and in inhibition of tumor necrosis factor α (TNF-α)- induced phosphorylation in human aortic smooth muscle cells.

AUDA may be used in soluble epoxide hydrolase-mediated cell signaling studies.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Inhibition of soluble epoxide hydrolase by AUDA inhibits the metabolism of epoxyeicosatrienoic acids (EETs) and protects end-organs against the damaging effects of salt-sensitive hypertension. AUDA also renders protection against myocardial ischemia-reperfusion injury and cerebral ischemia.

AUDA is a potent inhibitor of soluble epoxide hydrolase

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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