EMAIL THIS PAGE TO A FRIEND
SML0187 Sigma-Aldrich

CJ-13610

≥98% (HPLC)

Synonym: Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide

  • CAS Number 179420-17-8

  • Empirical Formula (Hill Notation) C22H23N3O2S

  • Molecular Weight 393.50

  •  MDL number MFCD00948114

  •  PubChem Substance ID 329825216

  •  NACRES NA.77

Purchase

Properties

Related Categories Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to tan
solubility   DMSO: ≥10 mg/mL
originator   Pfizer
storage temp.   2-8°C
SMILES string   Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2
InChI   1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)
InChI key   VPTONMHDLLMOOV-UHFFFAOYSA-N

Description

Application

CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC50 = 70 nM).

CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.

Features and Benefits

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Lipid Signaling Research

Within mammalian cells, a multitude of lipid compounds are found with a variety of cellular functions, including structural components of cell membranes and as second messengers in cell signaling pat...
Keywords: Absorption, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell signaling, Diabetes, Digestions, Diseases, Growth factors, Hormones, Inflammation, Lipid Metabolism, Lipid signaling, Metabolism

Leukotriene Receptors

Leukotrienes (LTs) exist as two distinct classes, hydroxyacids (such as LTB4), and cysteinyl leukotrienes (such as LTC4, LTD4 and LTE4). Leukotriene receptors have been classified into BLT and CysLT ...
Keywords: Addition reactions, Anti-inflammatory agents, Atomic absorption spectroscopy, Clinical, Diseases, Gene expression, Inflammation, Transduction

Prostanoid Receptors

Prostanoids comprise prostaglandins (PGs) and thromboxanes (Txs). Prostanoid receptors can be classified into five types on the basis of sensitivity to the five naturally-occurring ligands; PGD2, PGE...
Keywords: Atomic absorption spectroscopy, Gene expression, Individual protein Immunoprecipitation, Inflammation, Ligands, Metabolism, Transduction

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?