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SML0193 Sigma-Aldrich

JFD01307SC

≥95% (HPLC)

Synonym: N-(Tetrahydro-1,1-dioxido-3-thienyl)-glycine

  • CAS Number 51070-56-5

  • Empirical Formula (Hill Notation) C6H11NO4S

  • Molecular Weight 193.22

  •  PubChem Substance ID 329825219

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,
InChI Key   JQQXDZXXSDLRBC-UHFFFAOYSA-N
assay   ≥95% (HPLC)
form   powder
storage condition   desiccated
color   white to tan
solubility   DMSO: ≥5 mg/mL at ~60 °C
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Application

JFD01307SC may be used in glutamine synthetase-mediated cell signaling studies.

Biochem/physiol Actions

JFD01307SC is a glutamine synthetase inhibitor and anti-tuberculosis agent. It is believed to act as a mimic of L-Glutamate and thus target enzymes involved in glutamine biosynthesis. JFD01307SC showed activity against M. tuberculosis with MIC in the range of 8 to 16 μg/ml.

Features and Benefits

This compound is featured on the Glutamate/GABA Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Glutamate/GABA Synthesis and Metabolism

Glutamine is a common precursor for the biosynthesis of both glutamate and GABA. Glutamine can be transported in and out of neurons and astrocytes utilizing different glutamine carriers. Three such c...
Keywords: Anticonvulsants, Catalysis, Citric Acid Cycle, Gene expression, Metabolism, Neurotransmitters, Nuclear magnetic resonance spectroscopy, Schizophrenia, Spectroscopy, Transaminations

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