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SML0226 Sigma-Aldrich

Pseudocantharidin C

≥98% (HPLC)

Synonym: (4-Bromophenyl) ((3aR,4R,7S,7aS)-rel-4,7-Epoxy-1H-isoindol-2(3H,3aH,4H,5H,6H,7H,7aH)-yl)methanone

  • CAS Number 1301756-81-9

  • Empirical Formula (Hill Notation) C15H16BrNO2

  • Molecular Weight 322.20

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Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Pseudocantharidin C stimulates PP2A activity up to two-fold without influencing PP1. PP2A activation by pseudocantharidin C changes phosphorylation of tra2-beta1 at position T33 and promotes the SMN2 pre-mRNA exon 7 inclusion.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Phosphoprotein Phosphatases (Serine/Threonine)

Phosphoprotein phosphatases, which hydrolyze the phosphoester bonds of phosphoserines, phosphothreonines or phosphotyrosines, play an essential role in signal transduction and actively contribute to ...
Keywords: Catalysis, Cloning, Gene expression, Neurotransmitters, Phosphorylations, Transduction

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