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SML0256 Sigma-Aldrich

2OHOA

≥98% (HPLC)

Synonym: (9Z)-2-Hydroxy-9-octadecenoic acid; cis-2-Hydroxy-9-octadecenoic acid, 2-Hydroxy Oleic Acid, Minerval

  • CAS Number 56472-29-8

  • Empirical Formula (Hill Notation) C18H34O3

  • Molecular Weight 298.46

  •  MDL number MFCD07778553

  •  PubChem Substance ID 329825264

  •  NACRES NA.77

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Properties

Related Categories 0-9, Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   100
assay   ≥98% (HPLC)
storage condition   protect from light
color   white to tan
solubility   DMSO: >20 mg/mL
storage temp.   room temp
SMILES string   CCCCCCCC\C=C/CCCCCCC(O)C(O)=O
InChI   1S/C18H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h9-10,17,19H,2-8,11-16H2,1H3,(H,20,21)/b10-9-
InChI key   JBSOOFITVPOOSY-KTKRTIGZSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

2OHOA induces cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2OHOA increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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