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SML0259 Sigma-Aldrich

Catharanthine

≥95% (HPLC)

Synonym: (+)-3,4-Didehydrocoronaridine, (2α,5β,6α,18β)-3,4-Didehydroibogamine-18-carboxylic acid methyl ester, 7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1′,2′:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester

  • CAS Number 2468-21-5

  • Empirical Formula (Hill Notation) C21H24N2O2

  • Molecular Weight 336.43

  •  MDL number MFCD01753356

  •  PubChem Substance ID 329825267

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   CMKFQVZJOWHHDV-NQZBTDCJSA-N
Quality Level   100
assay   ≥95% (HPLC)
form   powder
optical activity   [α]/D +30 to +38° (c=0.5, CDCl3)
color   white to beige
solubility   DMSO: 5 mg/mL (clear solution; warmed)
shipped in   wet ice
storage temp.   −20°C

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Catharanthine is a precursor of the anti-tumor drugs vinblastine and vincristine, formed by dimerization of catharanthine with vindoline. Catharanthine itself is an inhibitor of tubulin self-assembly into microtubules, although not so potent as vinblastine or vincristine. Catharanthine also has anticholinergic activity. It showed muscarinic antagonism at 10 microM and fully inhibited nicotinic receptor mediated diaphragm contractions with an IC50 of 59.6 microM.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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