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SML0288 Sigma-Aldrich

Nepafenac

≥98% (HPLC)

Synonym: 2-Amino-3-benzoyl-benzeneacetamide, AHR 9434, AL 6515

  • CAS Number 78281-72-8

  • Empirical Formula (Hill Notation) C15H14N2O2

  • Molecular Weight 254.28

  •  MDL number MFCD08067732

  •  PubChem Substance ID 329825296

  •  NACRES NA.77

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Properties

Related Categories Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   faintly yellow to dark yellow
solubility   DMSO: ≥5 mg/mL
storage temp.   room temp
SMILES string   NC(=O)Cc1cccc(c1N)C(=O)c2ccccc2
InChI   1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
InChI key   QEFAQIPZVLVERP-UHFFFAOYSA-N
Gene Information   human ... PTGS1(5742), PTGS2(5743)

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery.

Nepafenac, a prodrug of amfenac, is used in the treatment of diabetic retinopathy. It is metabolized to its active form through intraocular enzymatic hydrolysis. Nepafenac has a molecular weight of 254.28 kDa and effectively penetrates through the cornea. Its molecule structure enables nepafenac to possess better permeability. Nepafenac has a low inhibitory effect on cyclooxygenase.

Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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