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SML0296 Sigma-Aldrich

Pyroxamide

≥97% (HPLC)

Synonym: N1-Hydroxy-N8-3-pyridinyl-octanediamide

  • CAS Number 382180-17-8

  • Empirical Formula (Hill Notation) C13H19N3O3

  • Molecular Weight 265.31

  •  MDL number MFCD13194970

  •  PubChem Substance ID 329825303

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥97% (HPLC)
form   powder
color   white to beige
solubility   DMSO: 10 mg/mL (clear solution)
storage temp.   −20°C
SMILES string   ONC(=O)CCCCCCC(=O)Nc1cccnc1
InChI   1S/C13H19N3O3/c17-12(15-11-6-5-9-14-10-11)7-3-1-2-4-8-13(18)16-19/h5-6,9-10,19H,1-4,7-8H2,(H,15,17)(H,16,18)
InChI key   PTJGLFIIZFVFJV-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Pyroxamide is an inhibitor of HDAC1 (IC50 = 100 nM). Pyroxamide induces apoptosis and cell cycle arrest in leukemia, bladder and prostate cancer cell lines.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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