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SML0308 Sigma-Aldrich

Carbazeran

≥95% (HPLC)

Synonym: N-Ethyl-carbamic acid 1-(6,7-dimethoxy-1-phthalazinyl)-4-piperidinyl ester, UK 31557

  • CAS Number 70724-25-3

  • Empirical Formula (Hill Notation) C18H24N4O4

  • Molecular Weight 360.41

  •  MDL number MFCD00867107

  •  PubChem Substance ID 329825313

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥95% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   DMSO: ≥2 mg/mL at warmed
storage temp.   2-8°C
SMILES string   CCNC(=O)OC1CCN(CC1)c2nncc3cc(OC)c(OC)cc23
InChI   1S/C18H24N4O4/c1-4-19-18(23)26-13-5-7-22(8-6-13)17-14-10-16(25-3)15(24-2)9-12(14)11-20-21-17/h9-11,13H,4-8H2,1-3H3,(H,19,23)
InChI key   QJGVXJYGDBSPSJ-UHFFFAOYSA-N

Description

General description

Carbazeran is usedin the treatment of heart failure.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Carbazeran is an Aldehyde oxidase (AO) substrate and a phosphodiesterase inhibitor that produces concentration-dependent positive inotropic responses. In humans, the compound is almost completely cleared via 4-hydroxylation to the phthalazinone metabolite by AO.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. They function with adenylyl and guanylyl cyclases to regulate the amplitude and duration of responses triggere...
Keywords: Amplification, Atomic absorption spectroscopy, Catalysis, Diabetes, Gene expression, Genetic, Hormones, Inflammation, Neurotransmitters, Obesity, Parkinson Disease, Phosphorylations, Physiological Processes, Schizophrenia, Transduction

Peer-Reviewed Papers
15

References

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