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SML0313 Sigma-Aldrich

Pimelic Diphenylamide 106

≥98% (HPLC)

Synonym: Compound 106, Inhibitor 106, N1-(2-Aminophenyl)-N7-(4-methylphenyl)-heptanediamide, RGFA 8, TC-H 106

  • CAS Number 937039-45-7

  • Empirical Formula (Hill Notation) C20H25N3O2

  • Molecular Weight 339.43

  •  MDL number MFCD17010287

  •  PubChem Substance ID 329825318

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: ≥15 mg/mL
storage temp.   2-8°C
SMILES string   Cc1ccc(NC(=O)CCCCCC(=O)Nc2ccccc2N)cc1
InChI   1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)
InChI key   WTKBRPXPNAKVEQ-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

106 is a Class I HDAC inhibitor, demonstrating no activity against class II HDACs. It is a slow, tight-binding inhibitor of HDACs 1, 2, and 3, with a preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.

Pimelic diphenylamides has the ability to enhance the expression of the frataxin gene in lymphocytes from Friedreich ataxia patients.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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