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SML0315 Sigma-Aldrich

CORM-A1

≥95% (NMR)

Synonym: Sodium boranocarbonate

  • CAS Number 17363-08-5

  • Empirical Formula (Hill Notation) CH3BNa2O2

  • Molecular Weight 103.82

  •  MDL number MFCD18839226

  •  PubChem Substance ID 329825320

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥95% (NMR)
form   powder
storage condition   desiccated
color   white to beige
solubility   H2O: >15 mg/mL
storage temp.   room temp
SMILES string   [Na+].[Na+].[BH3-]C([O-])=O
InChI   1S/CH4BO2.2Na/c2-1(3)4;;/h2H3,(H,3,4);;/q-1;2*+1/p-1
InChI key   SOFPSQNQOQPAAJ-UHFFFAOYSA-M

Description

Application

CORM-A1 has been used:
• to deliver carbon monoxide (CO) and to test its cytoprotection in yeast and primary astrocytes culture during oxidative stress
• as CO donor in murine macrophages J774A.1 cells to test its effect on cellular β-endorphins elevation
• to test its effect on mitophagy activation in retinal ganglion cells

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

CORM-A1 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase is an important gaseous signaling mediator in mammalian cells CORM-A1 has anti-oxidant and anti-inflammatory activity.

It mediates the release of CO in a pH and temperature-dependent manner, thus favoring mild vasorelaxation and hypotension. During oxidative stress, CORM-A1 is reported to provide cytoprotection in astrocyte primary cultures. This boron-containing CORM promotes autophagy.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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