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SML0325 Sigma-Aldrich

Retigabine

≥98% (HPLC)

Synonym: D-23129, Ezogabine, N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester

  • CAS Number 150812-12-7

  • Empirical Formula (Hill Notation) C16H18FN3O2

  • Molecular Weight 303.33

  •  Beilstein/REAXYS Number 8072099

  •  MDL number MFCD04307735

  •  PubChem Substance ID 329825330

  •  NACRES NA.77

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Potassium Channel Modulators,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
drug control   USDEA Schedule V
color   white to light brown
solubility   DMSO: >15 mg/mL
storage temp.   room temp
SMILES string   FC1=CC=C(CNC2=CC(N)=C(NC(OCC)=O)C=C2)C=C1
InChI   1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
InChI key   PCOBBVZJEWWZFR-UHFFFAOYSA-N
Gene Information   human ... KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479)

Description

Biochem/physiol Actions

Retigabine (Ezogabine) is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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