EMAIL THIS PAGE TO A FRIEND
SML0339 Sigma-Aldrich

Tideglusib

≥98% (HPLC)

Synonym: 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione, NP-12, NP031112

  • CAS Number 865854-05-3

  • Empirical Formula (Hill Notation) C19H14N2O2S

  • Molecular Weight 334.39

  •  MDL number MFCD18633296

  •  PubChem Substance ID 329825344

  •  NACRES NA.77

Purchase

Properties

Related Categories Alzheimer′s Disease, Assays/Reagents for Alzheimer′s Disease Research, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   DMSO: >15 mg/mL
storage temp.   2-8°C
SMILES string   O=C1SN(C(=O)N1Cc2ccccc2)c3cccc4ccccc34
InChI   1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
InChI key   PMJIHLSCWIDGMD-UHFFFAOYSA-N

Description

Application

Tideglusib has been used:
• as a reference compound in ADP-GloTM Kinase assay
• as an allosteric inhibitor of GSK-3β to study its effects on myocardial remodeling and angiogenesis
•  as a differentiation agent (specifically a glycogen synthase kinase (GSK)-3β inhibitor) to convert fibroblast cells into octamer-binding transcription factor-4 (OCT4)+ and vascular endothelial growth factor receptor-2 (VEGFR-2/fetal liver kinase-1 (FLK1)+ cells

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Tideglusib, also known as NP031112 or NP-12, is a potent non ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK3), an important kinase studied in stem cell research and neurodegenerative diseases. It is currently in clinical trials for Alzheimer′s disease and Progressive Supranuclear Palsy (PSP). Tideglusib reduces phosphorylation of the tau protein and the accumulation of amyloid plaques, reduces hippocampal and entorhinal cortex neuron loss and improves spatial memory deficits. It has also shown neuroprotective and anti-inflammatory activity in a variety of animal models.

Features and Benefits

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

GSK-3

GSK-3 is a highly conserved family of protein kinases. In humans, two genes encode two distinct, but closely related GSK-3 forms, referred to as GSK-3α and GSK-3β. They display 84% overall identity a...
Keywords: Alzheimer Disease, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Catalysis, Cell division, Diabetes, Diseases, Huntington Disease, Ligands, Neurodegenerative Diseases, Parkinson Disease, Phosphorylations, Schizophrenia, Transcription, Transduction

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?